Endocrine Abstracts

Medical treatment of acromegaly is based on either suppressing pituitary growth hormone (GH) secretion or by inhibiting GH action by preventing interaction with its receptor in order to suppress the elevated levels of insulin-like growth factor 1 (IGF1). AZP-3813 is a 16-amino acid, bicyclic peptide antagonist of the GH receptor (GHR) with KD of 1.9 nM for the human GHR. Previously, AZP-3813 was demonstrated to suppress IGF1 secretion in juvenile rats in a dose-rela...

While somatostatin analogs (SSA) are the primary medical therapy for treatment of acromegaly, they fail to normalize insulin-like growth factor 1 (IGF1) levels in the majority of patients when used as monotherapy. Even in patients with controlled IGF1, growth hormone (GH) levels can remain elevated and induce symptoms by interacting with GH receptors throughout the body. AZP-3813 is a 16-amino acid, bicyclic peptide GH receptor antagonist (GHRA) which has been demonstrated to ...